Enhancer ID: | E_02_249 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr11:6639029-6644397 |
|
Biosample name: | Mammary | |
Experiment class : | Low+High throughput |
Enhancer type: | Super-Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 30285185 |
Enhancer experiment: | ChIP-seq | |
Enhancer experiment description: | Employ_x0002_ing ChIP-seq, we uncover a changing transcription factor occupancy at mammary enhancers, suggest_x0002_ing that their activities evolve with advancing dif_x0002_ferentiation. |
Target gene : | Wap(Wap) | |
Strong evidence: | CRISPR/Cas9 | |
Less strong evidence: | qRT-PCR,ChIP-seq | |
Target gene experiment description: | Most profoundly, a seed enhancer, which is manda_x0002_tory for the activation of the Wap super-enhancer during pregnancy, is not required during lactation,suggesting compensatory flexibility. Combinatorial deletions of structurally equivalent constituent en_x0002_hancers demonstrated differentiation-specific com_x0002_pensatory activities during lactation. |
TF name : | Stat5a(AA959963,STAT5)Nr3c1(GCCR,GCR,GCRST,GR,GRL) | |
TF experiment: | ChIP-seq | |
TF experiment description: | Employ_x0002_ing ChIP-seq, we uncover a changing transcription factor occupancy at mammary enhancers, suggest_x0002_ing that their activities evolve with advancing dif_x0002_ferentiation. |
Enhancer function : | Wap super-enhancer evolve as lactation progresses. |
Enhancer function experiment: | CRISPR/Cas9 |
Enhancer function experiment description: |
Using mouse genetics, we demonstrate that the functions of individual enhancers within the Wap super-enhancer evolve as lactation progresses. |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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