About Enhancer
| Enhancer ID: | E_02_248 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr11:6644257-6644824   |
|
| Biosample name: | Mammary | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 30285185 |
| Enhancer experiment: | ChIP-seq | |
| Enhancer experiment description: | Employ_x0002_ing ChIP-seq, we uncover a changing transcription factor occupancy at mammary enhancers, suggest_x0002_ing that their activities evolve with advancing dif_x0002_ferentiation. |
About Target gene
| Target gene : | Wap(Wap) | |
| Strong evidence: | CRISPR/Cas9 | |
| Less strong evidence: | qRT-PCR,ChIP-seq | |
| Target gene experiment description: | Most profoundly, a seed enhancer, which is manda_x0002_tory for the activation of the Wap super-enhancer during pregnancy, is not required during lactation,suggesting compensatory flexibility. Combinatorial deletions of structurally equivalent constituent en_x0002_hancers demonstrated differentiation-specific com_x0002_pensatory activities during lactation. |
About TF
| TF name : | Stat5a(AA959963,STAT5)Nr3c1(GCCR,GCR,GCRST,GR,GRL) | |
| TF experiment: | ChIP-seq | |
| TF experiment description: | Employ_x0002_ing ChIP-seq, we uncover a changing transcription factor occupancy at mammary enhancers, suggest_x0002_ing that their activities evolve with advancing dif_x0002_ferentiation. |
About Function
| Enhancer function : | Wap super-enhancer evolve as lactation progresses. |
| Enhancer function experiment: | CRISPR/Cas9 |
| Enhancer function experiment description: |
Using mouse genetics, we demonstrate that the functions of individual enhancers within the Wap super-enhancer evolve as lactation progresses. |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
