About Enhancer

Enhancer ID: E_02_226
Enhancer symbol: --
Species: Mouse
Position : chr19:61151074-61161722
Biosample name: Monocytes,Dendritic Cells
Experiment class : Low+High throughput
Enhancer type: Super-Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  29514092
Enhancer experiment: ChIP-seq
Enhancer experiment description: Active enhancers shared by monocytes and DCs (but not neutrophils) and those specific for monocytes were primed and activated with similar kinetics(Figure 2A, left and center). H3K4me1 and H3K27ac ChIP-seq tag densities in these enhancer regions initially increased at the MDP stage.Notably, the expression of genes with primed but not active (often called poised) enhancers was barely induced in monocytes and DCs (Figure S2). We found that the kinetics of DC-specific active enhancers were slower(Figure 2A, right);

About Target gene

Target gene : Csf2ra(CD116,Csfgmra,GM-CSFR,GM-CSF-Ra)
Strong evidence: --
Less strong evidence: ChIP-seq,Transgenic mice,RT-qPCR
Target gene experiment description: Representative genome browser images of monocyte- or DC-specific en_x0002_hancers, associated with the Bfsp1 and Ehf genes, respec_x0002_tively, are depicted in Figures 2B and 2C.Thus, monocyte_x0002_and/or DC-specific active enhancers are gradually established at progenitor stages prior to the expression of associated genes.

About TF

TF name : Irf8(H-ICSBP,ICSBP,ICSBP1,IMD32A,IMD32B,IRF-8)
TF experiment: ChIP-seq,Transgenic mice
TF experiment description: Analysis of Enhancer landscapes in Irf8–/– mononuclear phagocyte progenitors and ChIP-seq of IRF8 binding sites in wild-type (WT) cells uncovered a critical role for IRF8.Using an in vitro monocyte differentiation system, we additionally showed that IRF8 binds to promoter-distal enhancers and promotes H3K4me1 enrichment at its binding sites.Consistent with these data, the correlation coefficient of H3K4me1 ChIP-seq tag densities between WT MDPs and Irf8–/– MDPs was lower than that of the microarray data.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
--

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs