About Enhancer

Enhancer ID: E_02_218
Enhancer symbol: --
Species: Mouse
Position : chr2:75120051-75165771
Biosample name: Murine Limb Bud Cells
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  29273679
Enhancer experiment: Hi-C,4C,ChIP-seq
Enhancer experiment description: In order to gain insights into TAD organization around the HoxD locus during limb bud development, we performed Hi-C (chromosome capture followed by high-throughput sequencing) on microdissected distal and proximal limb bud cells isolated from embryonic day 12.5 (E12.5) embryos. At this stage, T-DOM enhancers regulate Hoxd gene expression in proximal cells and are silent in distal cells, whereas C-DOM enhancers control Hoxd gene targets in future digit cells and are silent in proximal cells. Therefore, the two TADs are either transcriptionally active or inactive in an exclusive manner in the two tissue samples (Fig. 1A,B, top schemes).

About Target gene

Target gene : Hoxd
Strong evidence: 4C
Less strong evidence: Hi-C,qPCR
Target gene experiment description: Consequently,under wild-type conditions, Hoxd4 is expressed only in proximal limb cells under the control of the T-DOM,while C-DOM Enhancers control Evx2 transcripts in dis_x0002_tal cells exclusively.

About TF

TF name : --
TF experiment: --
TF experiment description: --

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
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About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs