About Enhancer
| Enhancer ID: | E_02_209 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr1:131920349-131962471   |
|
| Biosample name: | Liver,Kidney | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 29254942 |
| Enhancer experiment: | 4C-seq,Transgenic mice,RNA-seq | |
| Enhancer experiment description: | Chromosome conformation capture (4C-seq) in liver and kidney identified liver-specific chromatin loops that recruited clock-bound enhancers to promoters to regulate liver-specific transcriptional rhythms. |
About Target gene
| Target gene : | Slc45a3(2210413P12Rik,AU023994,AU043764,IPCA-6,PRST,Pcanap6) | |
| Strong evidence: | 4C-seq | |
| Less strong evidence: | Transgenic mice,RNA-seq | |
| Target gene experiment description: | Targeting the Slc45a3-short promoter with 4C-seq in liver and kidney showed liverspecific chromatin loops at three distal regions (two upstream, one downstream) (Figure 6A). |
About TF
| TF name : | Rore(9530021D13Rik,Nr1f1,ROR1,ROR2,ROR3,nmf267,sg,staggerer,tmgc26)Onecut1(D9Ertd423e,HNF-6,Hfh12,Hnf6,Hnf6b,OC-1,Oc1)Foxa | |
| TF experiment: | ChIP-seq | |
| TF experiment description: | These liver-specific DHSs were bound by liver-specific TFs, FOXA2 and ONECUT2, and clock TF, REVERBa, as shown in ChIP-seq. |
About Function
| Enhancer function : | Enhancers can contact a rhythmic promoter while looping out nearby nonrhythmic alternative promoters, confining rhythmic enhancer activity to specific promoters |
| Enhancer function experiment: | 4C-seq |
| Enhancer function experiment description: |
Chromosome conformation capture (4C-seq) in liver and kidney identified liver-specific chromatin loops that recruited clock-bound Enhancers to promoters to regulate liver-specific transcriptional rhythms. |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
