About Enhancer
| Enhancer ID: | E_02_205 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr2:122651534-122668846   |
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| Biosample name: | Macrophage | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 29133016 |
| Enhancer experiment: | 3C-seq,ChIP-seq | |
| Enhancer experiment description: | Next, we identified an enhancer set associated with LPS-responsive pri-miRNAs based on publicly available H3K4 mono-methylation-specific ChIP-seq and GRO-seq datasets. This enhancer set was further characterized by the combination of publicly available ChIP and ATAC-seq datasets. Finally, direct interactions between the miR-155-coding genomic region and its distal regulatory elements were identified using a 3C-seq approach. |
About Target gene
| Target gene : | Tlr4(Lps,Ly87,Ran/M1,Rasl2-8) | |
| Strong evidence: | 3C-seq | |
| Less strong evidence: | RT-qPCR,ChIP-seq,ATAC-seq | |
| Target gene experiment description: | This Enhancer set was further characterized by the combination of publicly available ChIP and ATAC-seq datasets.Finally,direct interactions between the miR-155-coding genomic region and its distal regulatory elements were identified using a 3C-seq approach. |
About TF
| TF name : | NFKB1(CVID12,EBP-1,KBF1,NF-kB,NF-kB1,NF-kappa-B1,NF-kappaB,NFKB-p105,NFKB-p50,NFkappaB,p105,p50)Junb(AP-1) | |
| TF experiment: | ChIP-seq | |
| TF experiment description: | As expected, de novo motif analysis under NFkB-p65 and JunB peaks revealed significant enrichment of NFkB-p65 and Jun-AP1 motifs (Supplementary Figure 3B and C). Targeted motif discovery at the LPS-responsive pri-miRNAs-associated enhancer subsets showed that both NFkB-p65 and Jun-AP1 motifs were found a higher number at the p65high enhancers compared to the p65low and LPS-repressed enhancers (Figure 3D). |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
