About Enhancer
| Enhancer ID: | E_02_204 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr14:18175266-18186392   |
|
| Biosample name: | Hepatocellular Carcinoma | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | Hepatocellular Carcinoma | |
| DO: | DOID:684 | |
| Mesh: | D006528 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 29113912 |
| Enhancer experiment: | ChIP-seq | |
| Enhancer experiment description: | Notably, histone modification markers, including H3K4me1,H3K4me3, H3K27me3 and H3K27ac were presented at the Ang2 gene locus in liver tumor cells and were strongly colocal_x0002_ized with the two Arid1a-binding sites, suggesting an associa_x0002_tion between Arid1a binding and histone modification at the Ang2 gene locus (Fig. 4A). ChIP-qPCR analysis showed Arid1a knockdown increased the H3K27ac at the Ang2 proximal and distal regions. |
About Target gene
| Target gene : | Ang2(Angrp,Raa3,Rnase5b) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq,ChIP-qPCR | |
| Target gene experiment description: | Notably, histone modification markers, including H3K4me1,H3K4me3, H3K27me3 and H3K27ac were presented at the Ang2 gene locus in liver tumor cells and were strongly colocal_x0002_ized with the two Arid1a-binding sites, suggesting an associa_x0002_tion between Arid1a binding and histone modification at the Ang2 gene locus (Fig. 4A). ChIP-qPCR analysis showed Arid1a knockdown increased the H3K27ac at the Ang2 proximal and distal regions. |
About TF
| TF name : | Ep300(KAT3B,MKHK2,RSTS2,p300) | |
| TF experiment: | ChIP-seq,ChIP-PCR | |
| TF experiment description: | Interestingly,published ChIP-seq data also showed that p300 bound to the Ang2 gene locus, as we validated by ChIP-PCR. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
