Enhancer ID: | E_02_187 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr6:88202011-88204330 |
|
Biosample name: | Embryonic Endothelial Cell | |
Experiment class : | Low+High throughput |
Enhancer type: | Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 28121289 |
Enhancer experiment: | Luciferase Reporter Assay,ChIP-seq,Western blot | |
Enhancer experiment description: | Viewing Ep300fb bioChiP-seq signal at genes selectively expressed in heart or brain confirmed robust tissue-specific differences that overlapped enhancers with known tissue-specific activity.To further functionally validate the transcriptional activity of these heterodimer motifs, we measured their enhancer activity using luciferase reporter assays. |
Target gene : | Gata2(Gata-2) | |
Strong evidence: | -- | |
Less strong evidence: | Luciferase Reporter Assay,ChIP-seq | |
Target gene experiment description: | At the skeletal muscle specific gene Myod, Myf5Cre drove strong Ep300fb bioChiP-seq signal at a known distal Enhancer (Goldhamer et al., 1992), as well as a second Ep300 bound region about 12 kb upstream from the transcriptional start site. |
TF name : | Ep300(KAT3B,MKHK2,RSTS2,p300) | |
TF experiment: | ChIP-seq | |
TF experiment description: | However, antibodies for Ep300 are marginal for robust ChIP-seq, particularly from tissues, leading to low reproducibility, variation between antibody lots, and inefficient Enhancer identification. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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