About Enhancer

Enhancer ID: E_02_187
Enhancer symbol: --
Species: Mouse
Position : chr6:88202011-88204330
Biosample name: Embryonic Endothelial Cell
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  28121289
Enhancer experiment: Luciferase Reporter Assay,ChIP-seq,Western blot
Enhancer experiment description: Viewing Ep300fb bioChiP-seq signal at genes selectively expressed in heart or brain confirmed robust tissue-specific differences that overlapped enhancers with known tissue-specific activity.To further functionally validate the transcriptional activity of these heterodimer motifs, we measured their enhancer activity using luciferase reporter assays.

About Target gene

Target gene : Gata2(Gata-2)
Strong evidence: --
Less strong evidence: Luciferase Reporter Assay,ChIP-seq
Target gene experiment description: At the skeletal muscle specific gene Myod, Myf5Cre drove strong Ep300fb bioChiP-seq signal at a known distal Enhancer (Goldhamer et al., 1992), as well as a second Ep300 bound region about 12 kb upstream from the transcriptional start site.

About TF

TF name : Ep300(KAT3B,MKHK2,RSTS2,p300)
TF experiment: ChIP-seq
TF experiment description: However, antibodies for Ep300 are marginal for robust ChIP-seq, particularly from tissues, leading to low reproducibility, variation between antibody lots, and inefficient Enhancer identification.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
--

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs