About Enhancer

Enhancer ID: E_02_137
Enhancer symbol: --
Species: Mouse
Position : chr1:13041306-13127367
Biosample name: Embryonic Stem Cell
Experiment class : Low throughput
Enhancer type: Super-Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  25801169
Enhancer experiment: Luciferase Reporter Assay
Enhancer experiment description: The five super-enhancers show physical interactions with their respective associated genes and are located within insulated neighborhoods in the ESC genome , suggesting that these genes represent the bona fide physiological targets of the five SEs.

About Target gene

Target gene : Prdm14(Prdm14)
Strong evidence: CRISPR/Cas9
Less strong evidence: --
Target gene experiment description: The results showed that deletion of most (12/14) super-enhancer constituents led to reduced expression of the associated gene, while in one case (Prdm14 E5) the deletion caused a small increase in expression of the associated gene

About TF

TF name : Oct4Sox2(ANOP3,MCOPS3)Nanog(NANOG)
TF experiment: ChIP-seq
TF experiment description: ChIP-Seq binding profiles for OCT4,SOX2 and NANOG (merged) and Mediator (MED1) at the miR-290-295 locus in ES cells.Enhancer activity measured in luciferase reporter assays in wild type cells and the change in enhancer activity after OCT4 shutdown is plotted for each constituent enhancer within the super-enhancer. The super-enhancer is depicted as a black bar above the binding profiles. The difference in values after OCT4 shutdown is statistically significant for all constituents, except from miR-290-295 M1, M3 and M5.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
--

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs