Enhancer ID: | E_02_137 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr1:13041306-13127367 |
|
Biosample name: | Embryonic Stem Cell | |
Experiment class : | Low throughput |
Enhancer type: | Super-Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 25801169 |
Enhancer experiment: | Luciferase Reporter Assay | |
Enhancer experiment description: | The five super-enhancers show physical interactions with their respective associated genes and are located within insulated neighborhoods in the ESC genome , suggesting that these genes represent the bona fide physiological targets of the five SEs. |
Target gene : | Prdm14(Prdm14) | |
Strong evidence: | CRISPR/Cas9 | |
Less strong evidence: | -- | |
Target gene experiment description: | The results showed that deletion of most (12/14) super-enhancer constituents led to reduced expression of the associated gene, while in one case (Prdm14 E5) the deletion caused a small increase in expression of the associated gene |
TF name : | Oct4Sox2(ANOP3,MCOPS3)Nanog(NANOG) | |
TF experiment: | ChIP-seq | |
TF experiment description: | ChIP-Seq binding profiles for OCT4,SOX2 and NANOG (merged) and Mediator (MED1) at the miR-290-295 locus in ES cells.Enhancer activity measured in luciferase reporter assays in wild type cells and the change in enhancer activity after OCT4 shutdown is plotted for each constituent enhancer within the super-enhancer. The super-enhancer is depicted as a black bar above the binding profiles. The difference in values after OCT4 shutdown is statistically significant for all constituents, except from miR-290-295 M1, M3 and M5. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
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SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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