About Enhancer
| Enhancer ID: | E_02_115 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr4:66837166-66852551   |
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| Biosample name: | Dendritic Cells | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 25453760 |
| Enhancer experiment: | ChIP-seq,ATAC-seq | |
| Enhancer experiment description: | analysis of active enhancers (H3K27ac) revealed the same relationship between H3K27ac intensity and cell type specific genes. ChIP-Seq of in vivo splenic pDCs showed similar patterns to our in vitro pDC model with respect to H3K4me1 and H3K28ac in enhance |
About Target gene
| Target gene : | Tlr4(Lps,Ly87,Ran/M1,Rasl2-8) | |
| Strong evidence: | -- | |
| Less strong evidence: | qPCR,RNA-seq,Western blot | |
| Target gene experiment description: | Specifically,we profiled genome-wide epigenetic modifications corresponding to candidate Enhancers (monomethylation of histone 3 lysine 4,H3K4me1),active Enhancers (H3K27ac) and promoter regions (H3K4me3) in both moDCs and pDCs. |
About TF
| TF name : | Tcf4(E2-2,FECD3,ITF-2,ITF2,PTHS,SEF-2,SEF2,SEF2-1,SEF2-1A,SEF2-1B,SEF2-1D,TCF-4,bHLHb19)Spib(Spi-B)Bcl11a | |
| TF experiment: | ChIP | |
| TF experiment description: | Molecularly,pDCs display many features of lymphocytes such as the B cell marker (B220),nucleic acid-sensing TLRs (TLR7,9) and transcription factors (Tcf4,SpiB,Bcl11a),whereas cDCs and moDCs express high levels of receptors that sense bacterial components (TLR 2,4) and inflammatory response genes. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
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About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
