About Enhancer
| Enhancer ID: | E_02_108 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr11:35178343-35180368   |
|
| Biosample name: | Tet2-/- | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 25263596 |
| Enhancer experiment: | ChIP-seq,ChIP | |
| Enhancer experiment description: | We therefore hypothesized that loss of Tet2 could lead to reduced oxidation and increased 5mC at enhancers. Indeed, hypermethylated DMRs (hyper-DMRs) in Tet5−/− cells exhibit several hallmarks of enhancers including: evolutionary sequence conservation,enrInstance": 858, "TopActivityInstance": 856, "Success": true} |
About Target gene
| Target gene : | Slit3(Slil2,Slit1,b2b2362.1Clo) | |
| Strong evidence: | -- | |
| Less strong evidence: | PCR,Transgenic mice | |
| Target gene experiment description: | we also differentiated a previously reported Tet2 knockdown mESC line and performed quantitative real-time PCR analysis. Consistent with our observations in TET2−/− mESCs, we also find delayed induction of the three marker genes slit3, lmo4, and irx3 |
About TF
| TF name : | Oct4Sox2(ANOP3,MCOPS3)Nanog(NANOG) | |
| TF experiment: | ChIP-seq | |
| TF experiment description: | Weaker occupancy of the ES-cell core transcription factors (TFs) OCT4,SOX2,and NANOG than those that do not change DNA methylation status. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
