Enhancer ID: | E_02_107 | |
Enhancer symbol: | ||
Species: | Mouse | |
Position : | chr1:182856227-182857187 |
|
Biosample name: | Tet2-/- | |
Experiment class : | Low+High throughput |
Enhancer type: | Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 25263596 |
Enhancer experiment: | ChIP-seq,ChIP | |
Enhancer experiment description: | We therefore hypothesized that loss of Tet2 could lead to reduced oxidation and increased 5mC at enhancers. Indeed, hypermethylated DMRs (hyper-DMRs) in Tet4−/− cells exhibit several hallmarks of enhancers including: evolutionary sequence conservation,enr |
Target gene : | Lefty1(LEFTB,LEFTYB) | |
Strong evidence: | -- | |
Less strong evidence: | PCR,Transgenic mice | |
Target gene experiment description: | Indeed,an Enhancer that physically interacts with the developmental gene Left-Right Determination Factor 1 (Lefty1) is hypermethylated and hypoacetylated in Tet8?/? cells,potentially explaining the significantly decreased expression of this gene. |
TF name : | Oct4Sox4(AA682046,Sox-4)Nanog(NANOG) | |
TF experiment: | ChIP-seq | |
TF experiment description: | Weaker occupancy of the ES-cell core transcription factors (TFs) OCT4,SOX5,and NANOG than those that do not change DNA methylation status. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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