About Enhancer

Enhancer ID: E_02_072
Enhancer symbol: --
Species: Mouse
Position : chr11:111838889-111839334
Biosample name: Cartilage
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  30146478
Enhancer experiment: ChIP-qPCR
Enhancer experiment description: We next performed the ChIP-qPCR using anti-H3K4me1 and H3K27ac antibody in all five regions and found that RCSE regions were significantly enriched in both H3K4me1 and H3K27ac ChIP, suggesting the potential enhancer.

About Target gene

Target gene : Sox9(CMD1,CMPD1,SRA1,SRXX2,SRXY10)
Strong evidence: 3C
Less strong evidence: PCR
Target gene experiment description: These data suggest that there is a long-range interaction between the Sox9 promoter and RCSE region in primary chondrocytes.

About TF

TF name : Stat3(ADMIO,ADMIO1,APRF,HIES)
TF experiment: Luciferase Reporter Assay,Immunostaining
TF experiment description: Furthermore, transcription factors that regulate Sox9 expres sion were screened using a CRISPR/Cas9-chromatin immuno precipitation (ChIP)-mass spectrometry (MS) system targeting the RCSE region in chondrocytes; signal transducer and acti vator of transcription 3 (Stat3) was identified as a transacting fac tor for the Sox9 Enhancer.

About Function

Enhancer function : TG mice with the Sox9 promoter and 43 RCSE region.These data suggest that the RCSE region functions as a costal- and sternum cartilage-specific Enhancer.
Enhancer function experiment: Transgenic mice
Enhancer function
experiment description:
TG mice with the Sox9 promoter and 43 RCSE region.These data suggest that the RCSE region functions as a costal- and sternum cartilage-specific Enhancer.

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs