About Enhancer
Enhancer ID: |
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E_02_072 |
Enhancer symbol: |
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-- |
Species: |
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Mouse |
Position : |
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chr11:111838889-111839334
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Biosample name: |
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Cartilage |
Experiment class : |
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Low+High throughput |
Enhancer type: |
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Enhancer |
Disease: |
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-- |
DO: |
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-- |
Mesh: |
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-- |
Distance from TSS: |
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>2KB |
Pubmed ID: |
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30146478 |
Enhancer experiment: |
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ChIP-qPCR |
Enhancer experiment description: |
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We next performed the ChIP-qPCR using anti-H3K4me1 and H3K27ac antibody in all five regions and found that RCSE regions were significantly enriched in both H3K4me1 and H3K27ac ChIP, suggesting the potential enhancer. |
About Target gene
Target gene : |
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Sox9(CMD1,CMPD1,SRA1,SRXX2,SRXY10) |
Strong evidence: |
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3C |
Less strong evidence: |
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PCR |
Target gene experiment description: |
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These data suggest that there is a long-range interaction between the Sox9 promoter and RCSE region in primary chondrocytes. |
About TF
TF name : |
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Stat3(ADMIO,ADMIO1,APRF,HIES) |
TF experiment: |
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Luciferase Reporter Assay,Immunostaining |
TF experiment description: |
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Furthermore, transcription factors that regulate Sox9 expres sion were screened using a CRISPR/Cas9-chromatin immuno precipitation (ChIP)-mass spectrometry (MS) system targeting the RCSE region in chondrocytes; signal transducer and acti vator of transcription 3 (Stat3) was identified as a transacting fac tor for the Sox9 Enhancer. |
About Function
Enhancer function : |
TG mice with the Sox9 promoter and 43 RCSE region.These data suggest that the RCSE region functions as a costal- and sternum cartilage-specific Enhancer. |
Enhancer function experiment: |
Transgenic mice |
Enhancer function experiment description: |
TG mice with the Sox9 promoter and 43 RCSE region.These data suggest that the RCSE region functions as a costal- and sternum cartilage-specific Enhancer. |
About SNP
SNP ID: |
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-- |
SNP position: |
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-- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs