About Enhancer
| Enhancer ID: | E_02_057 | |
| Enhancer symbol: | -- | |
| Species: | Mouse | |
| Position : | chr6:122726952-122727236   |
|
| Biosample name: | N2a | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | <2KB | |
| Pubmed ID: | 23321477 |
| Enhancer experiment: | Transfection,Luciferase Reporter Assay,PCR,EMSA,ChIP | |
| Enhancer experiment description: | Transient transfection assays in N2A neuroblasts using murine glut3-luciferase reporter constructs mapped the hypoxia-induced enhancer activities to -857- to -573-bp and -203- to -177-bp regions. |
About Target gene
| Target gene : | Slc2a3(GLUT3) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP | |
| Target gene experiment description: | Hypoxia-exposed N2A nuclear extracts demonstrated an increase in HIF-1a and p-Creb binding to HRE (-828 to -824 bp) and AP-1 (-187 to -180 bp) cis-elements, respectively, in electromobility shift and supershift assays, which was confirmed by chromatin immunoprecipitation assays. |
About TF
| TF name : | Hif1a(HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8,bHLHe78)Creb1(2310001E10Rik,3526402H21Rik,AV083133,Creb,Creb-1) | |
| TF experiment: | ChIP,EMSA | |
| TF experiment description: | Hypoxia-exposed N2A nuclear extracts demonstrated an increase in HIF-1α and p-Creb binding to HRE (-828 to -824 bp) and AP-1 (-187 to -180 bp) cis-elements, respectively, in electromobility shift and supershift assays, which was confirmed by chromatin immunoprecipitation assays. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
