Enhancer ID: | E_02_035 | |
Enhancer symbol: | -- | |
Species: | Mouse | |
Position : | chr11:32249976-32252156 |
|
Biosample name: | Primary Erythroid Cell | |
Experiment class : | Low+High throughput |
Enhancer type: | Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 22264824 |
Enhancer experiment: | RT-PCR,ChIP,ChIP-seq | |
Enhancer experiment description: | Beyond this AFE the isoform structure appears identical to the full-length transcript. Interestingly, the AFE coincides with one of the known intragenic enhancers.First, we tested wild-type mouse tissues by RT-PCR to verify the existence of this alternative transcript. |
Target gene : | Nprl3(Aag,CGTHBA,HS-26,HS-40,Mare,Phg,Prox1,m(alpha)RE) | |
Strong evidence: | -- | |
Less strong evidence: | RT-PCR,ChIP,ChIP-seq | |
Target gene experiment description: | Beyond this AFE the isoform structure appears identical to the full-length transcript. Interestingly, the AFE coincides with one of the known intragenic enhancers.First, we tested wild-type mouse tissues by RT-PCR to verify the existence of this alternative transcript. |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | Intragenic Enhancers frequently act as alternative tissue_x005f_x0002_specific promoters producing a class of abundant,spliced, multiexonic poly(A)+ RNAs (meRNAs) which reflect the host gene’s structure. |
Enhancer function experiment: | ChIP,RT-PCR,ChIP-seq |
Enhancer function experiment description: |
To address this problem, we analyzed transcrip_x005f_x0002_tion of the Nprl3 gene after deleting its constitutive promoter. This revealed that intragenic Enhancers act as highly active, alternative tissue-specific promoters for the gene containing them. |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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