Enhancer ID: | E_02_023 | |
Enhancer symbol: | Il12b Enhancer | |
Species: | Mouse | |
Position : | chr11:44390342-44392251 |
|
Biosample name: | Myeloid Cells,T Cell | |
Experiment class : | Low throughput |
Enhancer type: | Enhancer | |
Disease: | Autoimmune and Inflammatory Diseases | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 21566115 |
Enhancer experiment: | Luciferase Reporter Assay,qRT-PCR | |
Enhancer experiment description: | We focused on a conserved enhancer about 10kb upstream of the Il12b start site that is targeted by TLR signaling to increase Il12b transcription in response to LPS (33). We made luciferase reporter constructs that fused the Il12b promoter to the upstream enhancer. |
Target gene : | Il12b(CLMF,CLMF2,IL-12B,IMD28,IMD29,NKSF,NKSF2) | |
Strong evidence: | -- | |
Less strong evidence: | Luciferase Reporter Assay,qRT-PCR | |
Target gene experiment description: | To search for transcription factors that could be involved in the suppression of Il12b transcription, we used qRT-PCR to measure the expression of transcription factor mRNAs induced by IL-10 in the presence of an inflammatory costimulus.We made luciferase reporter constructs that fused the Il12b promoter to the upstream enhancer. |
TF name : | Nfil3(AV225605,E4BP4) | |
TF experiment: | qRT-PCR,Luciferase Reporter Assay | |
TF experiment description: | A NFIL3 binding site is identified in the enhancer region of Il12b. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
Home | Browse | Search | Download | Genome-Browser | Submit | Contact | Help
Copyright © HMU | 黑ICP备16009434号-1 | Li C Lab