About Enhancer

Enhancer ID: E_02_023
Enhancer symbol: Il12b Enhancer
Species: Mouse
Position : chr11:44390342-44392251
Biosample name: Myeloid Cells,T Cell
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: Autoimmune and Inflammatory Diseases
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  21566115
Enhancer experiment: Luciferase Reporter Assay,qRT-PCR
Enhancer experiment description: We focused on a conserved enhancer about 10kb upstream of the Il12b start site that is targeted by TLR signaling to increase Il12b transcription in response to LPS (33). We made luciferase reporter constructs that fused the Il12b promoter to the upstream enhancer.

About Target gene

Target gene : Il12b(CLMF,CLMF2,IL-12B,IMD28,IMD29,NKSF,NKSF2)
Strong evidence: --
Less strong evidence: Luciferase Reporter Assay,qRT-PCR
Target gene experiment description: To search for transcription factors that could be involved in the suppression of Il12b transcription, we used qRT-PCR to measure the expression of transcription factor mRNAs induced by IL-10 in the presence of an inflammatory costimulus.We made luciferase reporter constructs that fused the Il12b promoter to the upstream enhancer.

About TF

TF name : Nfil3(AV225605,E4BP4)
TF experiment: qRT-PCR,Luciferase Reporter Assay
TF experiment description: A NFIL3 binding site is identified in the enhancer region of Il12b.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
--

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs