About Enhancer
| Enhancer ID: |
|
E_01_416 |
| Enhancer symbol: |
|
-- |
| Species: |
|
Human |
| Position : |
|
chr1:230293530-230305966
   |
| Biosample name: |
|
Hep G2 |
| Experiment class : |
|
Low+High throughput |
| Enhancer type: |
|
Enhancer |
| Disease: |
|
-- |
| DO: |
|
-- |
| Mesh: |
|
-- |
| Distance from TSS: |
|
>2KB |
| Pubmed ID: |
|
26817450 |
| Enhancer experiment: |
|
ChIP-seq,Luciferase Reporter Assay,EMSA |
| Enhancer experiment description: |
|
EMSA and luciferase assays were used to validate the allele specific binding and to test the enhancer activity of the regulatory element harboring the AS-SNP rs4846913 as well as the neighboring rs2144300 which are in high LD with rs4846914. |
About Target gene
| Target gene : |
|
GALNT2(GalNAc-T2) |
| Strong evidence: |
|
-- |
| Less strong evidence: |
|
GWAS |
| Target gene experiment description: |
|
Using luciferase assays we found that rs4846913 and the neighboring rs2144300 displayed allele specific enhancer activity. We propose that an inhibitor binds preferentially to the rs4846913-C allele with an inhibitory boost from the synergistic binding of other TFs at the neighboring SNP rs2144300. These events influence the transcription level of GALNT2. |
About TF
| TF name : |
|
ZBTB3(ZBTB3) |
| TF experiment: |
|
EMSA,Luciferase Reporter Assay |
| TF experiment description: |
|
Using luciferase assays we found that rs4846913 and the neighboring rs2144300 displayed allele specific enhancer activity. We propose that an inhibitor binds preferentially to the rs4846913-C allele with an inhibitory boost from the synergistic binding of other TFs at the neighboring SNP rs2144300. |
About Function
| Enhancer function : |
-- |
| Enhancer function experiment: |
-- |
Enhancer function
experiment description: |
-- |
About SNP
| SNP experiment: |
|
ChIP-seq,Luciferase Reporter Assay,EMSA |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs
