About Enhancer
| Enhancer ID: | E_01_414 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr2:221040922-221069549   |
|
| Biosample name: | Medulloblastoma Cell Lines | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer | |
| Disease: | Medulloblastoma | |
| DO: | DOID:0050902 | |
| Mesh: | D008527 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 26814967 |
| Enhancer experiment: | qPCR,ChIP-seq,RNA-seq,4C-seq | |
| Enhancer experiment description: | To deeply characterize the active cis-regulatory circuitry of a single disease entity, here medul_x0002_loblastoma, we performed high-resolution chromatin immuno_x0002_precipitation with sequencing (ChIP-seq) for active enhancers (H3K27ac) in 32 primary tumour specimens and three established cell lines. |
About Target gene
| Target gene : | HLX(HB24,HLX1) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq | |
| Target gene experiment description: | Compared to typ_x0002_ical enhancers, SEs showed higher occupancy of BRD4 and greater enhancer signal dynamic range between subgroups.Targets of differential enhancers contained within SEs included a large fraction of established medullo_x0002_blastoma signature genes, as well as novel candidates.Medulloblastoma SEs were inferred to regulate known Cancer Gene Census genes, including the aforemen_x0002_tioned ALK in WNT, SMO and NTRK3 in SHH, LMO1, LMO2, and MYC in Group 3, and ETV4 and PAX5 in Group 4, among others. |
About TF
| TF name : | POU5F1(OCT3,OCT4,OTF-3,OTF3,OTF4,Oct-3,Oct-4)SOX2(ANOP3,MCOPS3)NANOG(NANOG) | |
| TF experiment: | ChIP-seq | |
| TF experiment description: | Computational reconstruction of core regulatory circuitry identified a master set of transcription factors, validated by ChIP-seq, that is responsible for subgroup divergence, and implicates candidate cells of origin for Group 4. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
