Enhancer ID: | E_01_412 | |
Enhancer symbol: | -- | |
Species: | Human | |
Position : | chr5:893433-1083433 |
|
Biosample name: | Medulloblastoma Cell Lines | |
Experiment class : | Low+High throughput |
Enhancer type: | Super-Enhancer | |
Disease: | Medulloblastoma | |
DO: | DOID:0050902 | |
Mesh: | D008527 | |
Distance from TSS: | >2KB | |
Pubmed ID: | 26814967 |
Enhancer experiment: | qPCR,ChIP-seq,RNA-seq,4C-seq | |
Enhancer experiment description: | To deeply characterize the active cis-regulatory circuitry of a single disease entity, here medul_x0002_loblastoma, we performed high-resolution chromatin immuno_x0002_precipitation with sequencing (ChIP-seq) for active enhancers (H3K27ac) in 30 primary tumour specimens and three established cell lines. |
Target gene : | NKD2(Naked2) | |
Strong evidence: | -- | |
Less strong evidence: | ChIP-seq | |
Target gene experiment description: | Compared to typ_x0002_ical enhancers, SEs showed higher occupancy of BRD4 and greater enhancer signal dynamic range between subgroups.Targets of differential enhancers contained within SEs included a large fraction of established medullo_x0002_blastoma signature genes, as well as novel candidates.Medulloblastoma SEs were inferred to regulate known Cancer Gene Census genes, including the aforemen_x0002_tioned ALK in WNT, SMO and NTRK3 in SHH, LMO1, LMO2, and MYC in Group 3, and ETV4 and PAX5 in Group 4, among others. |
TF name : | POU5F1(OCT3,OCT4,OTF-3,OTF3,OTF4,Oct-3,Oct-4)SOX2(ANOP3,MCOPS3)NANOG(NANOG) | |
TF experiment: | ChIP-seq | |
TF experiment description: | Computational reconstruction of core regulatory circuitry identified a master set of transcription factors, validated by ChIP-seq, that is responsible for subgroup divergence, and implicates candidate cells of origin for Group 4. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
Home | Browse | Search | Download | Genome-Browser | Submit | Contact | Help
Copyright © HMU | 黑ICP备16009434号-1 | Li C Lab