About Enhancer

Enhancer ID: E_01_376
Enhancer symbol: --
Species: Human
Position : chr1:92567177-92569177
Biosample name: MCF-7
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: Adenoid Cystic Carcinoma
DO: DOID:0080202
Mesh: D003528
Distance from TSS: >2KB
Pubmed ID:  26829750
Enhancer experiment: Luciferase Reporter Assay,RT-PCR,ChIP,ChIP-seq
Enhancer experiment description: Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic carcinoma (ACC). Whole-genome sequencing data and chromatin maps highlight distinct chromosomal rearrangements that juxtapose super-enhancers to the MYB locus. Chromosome conformation capture confirms that the translocated enhancers interact with the MYB promoter.

About Target gene

Target gene : TGFBR3(BGCAN,betaglycan)
Strong evidence: 3C
Less strong evidence: ChIP,ChIP-seq
Target gene experiment description: To test whether specific enhancers within the translocated super_x0002_enhancers might activate the MYB promoter, we examined their physical proximity to the promoter using chromosome conforma_x0002_tion capture (3C).We also examined a second ACC with a MYB-TGFBR3 translocation. In this case, seven of the nine H3K27ac peaks tested interacted with the MYB promoter.

About TF

TF name : TP63 (AIS,B(p51A),B(p51B),EEC3,KET,LMS,NBP,OFC8,RHS,SHFM4,TP53CP,TP53L,TP73L,p40,p51,p53CP,p63,p73H,p73L)
TF experiment: ChIP-seq
TF experiment description: To directly test whether TP63 co-binds with MYB, we mapped binding of this transcription factor by ChIP-seq.Remarkably, we found that 81% of TP63-binding sites in ACC were co-bound by MYB.These data suggest that MYB,TP71 and Notch signaling may coordinately orchestrate the diverse expression programs in ACC.

About Function

Enhancer function : Here we identify the juxtaposition of super-enhancer regions to the MYB locus as the unifying feature of ACC translocations.Detailed genomic and epigenomic analyses of ACCs identify alternate rearrangements that translocate super-enhancers in the NFIB and
Enhancer function experiment: 3C
Enhancer function
experiment description:
To test whether specific enhancers within the translocated super_x0002_enhancers might activate the MYB promoter, we examined their physical proximity to the promoter using chromosome conforma_x0002_tion capture (3C).These data suggest that the translocations reposition super-enhancers that subsequently loop to the MYB promoter and sustain high-level MYB expression.

About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs