About Enhancer
| Enhancer ID: | E_01_343 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr10:33492690-33519530   |
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| Biosample name: | Normal Epidermal Cell | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | EEC syndrome | |
| DO: | DOID:0060782 | |
| Mesh: | C536189 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 30566872 |
| Enhancer experiment: | siRNA,ChIP-seq | |
| Enhancer experiment description: | Two clusters of active enhancers were bound by p63 . Regions in C3 showed higher p63-binding signals.nearby genes were involved in apoptosis and epidermis development. Regions in C4 had relatively lower p63-binding signals, and nearby genes were involved in keratinocyte differentiation. |
About Target gene
| Target gene : | NRP1(BDCA4,CD304,NP1,NRP,VEGF165R) | |
| Strong evidence: | -- | |
| Less strong evidence: | siRNA | |
| Target gene experiment description: | Indeed, we observed a clear decrease of H3K27ac signals at Enhancers that had higher H3K27ac signals and bound by RUNX1 in p63 mutant keratinocytes (Figure 6B; n = 6,035) in two biological replicas, such as Enhancers near NRP1, which is involved in angiogenesis . |
About TF
| TF name : | TP63(AIS,B(p51A),B(p51B),EEC3,KET,LMS,NBP,OFC8,RHS,SHFM4,TP53CP,TP53L,TP73L,p40,p51,p53CP,p63,p73H,p73L)RUNX1(AML1,AML1-EVI-1,AMLCR1,CBF2alpha,CBFA2,EVI-1,PEBP2aB,PEBP2alpha) | |
| TF experiment: | siRNA,qRT-PCR | |
| TF experiment description: | Gene expression analysis by qRT-PCR of TP63 and RUNX1 expression in TP63 knockdown (siTP63) compared to non-targeting siRNA (siNT) in control keratinocytes. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
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About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
