Enhancer ID: | E_01_308 | |
Enhancer symbol: | -- | |
Species: | Human | |
Position : | chr16:74568579-74583481 |
|
Biosample name: | A673/TR/shEF1 Cells | |
Experiment class : | Low throughput |
Enhancer type: | Super-Enhancer | |
Disease: | Ewing Sarcoma | |
DO: | DOID:3369 | |
Mesh: | D012512 | |
Distance from TSS: | >2KB | |
Pubmed ID: | 29416716 |
Enhancer experiment: | Luciferase Reporter Assay,qRT-PCR | |
Enhancer experiment description: | Expression of these genes appeared to be induced by EWSR1-FLI1-bound super-enhancers, which showed high activity in reporter assays.In fact, EWSR1-FLI1 is known to convert non-functional GGAA-microsatellites into potent enhancers to steer a large proportion of its target genes [24–26]. Strong EWSR1-FLI1-dependent enhancer activity of these GGAA-microsatellites in luciferase reporter assays was consistently observed. |
Target gene : | GLG1(CFR-1,ESL-1,MG-160,MG160) | |
Strong evidence: | -- | |
Less strong evidence: | qRT-PCR,ChIP-seq | |
Target gene experiment description: | These data in cell lines suggested that ATP1A1, BCL11B, and GLG1 may be direct EWSR1-FLI1 target genes. Testing this hypothesis involved analyzing available ChIP-Seq and DNase-Seq data generated in Ewing sarcoma cell lines, which showed strong EWSR1-FLI1-binding to GGAA-microsatellites close to these genes. |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
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SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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