About Enhancer

Enhancer ID: E_01_307
Enhancer symbol: --
Species: Human
Position : chr1:116896120-116904325
Biosample name: A673/TR/shEF1 Cells
Experiment class : Low throughput
Enhancer type: Super-Enhancer
Disease: Ewing Sarcoma
DO: DOID:3369
Mesh: D012512
Distance from TSS: >2KB
Pubmed ID:  29416716
Enhancer experiment: Luciferase Reporter Assay,qRT-PCR
Enhancer experiment description: Expression of these genes appeared to be induced by EWSR1-FLI1-bound super-enhancers, which showed high activity in reporter assays.In fact, EWSR1-FLI1 is known to convert non-functional GGAA-microsatellites into potent enhancers to steer a large proportion of its target genes [24–26]. Strong EWSR1-FLI1-dependent enhancer activity of these GGAA-microsatellites in luciferase reporter assays was consistently observed.

About Target gene

Target gene : ATP1A1(CMT2DD,HOMGSMR2)
Strong evidence: --
Less strong evidence: qRT-PCR,ChIP-seq
Target gene experiment description: These data in cell lines suggested that ATP1A1, BCL11B, and GLG1 may be direct EWSR1-FLI1 target genes. Testing this hypothesis involved analyzing available ChIP-Seq and DNase-Seq data generated in Ewing sarcoma cell lines, which showed strong EWSR1-FLI1-binding to GGAA-microsatellites close to these genes.

About TF

TF name : --
TF experiment: --
TF experiment description: --

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
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About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs