About Enhancer

Enhancer ID: E_01_285
Enhancer symbol:
Species: Human
Position : chr6:31092587-31094587
Biosample name: Human Corneal Epithelial Cells
Experiment class : Low+High throughput
Enhancer type: Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: --
Pubmed ID:  28916725
Enhancer experiment: Luciferase Reporter Assay,ChIP-seq
Enhancer experiment description: Because of their importance in controlling cell type–specific gene expression, we also defined SEs, using the strength of the H3K27ac mark as described previously (5, 6). We identified 1154 SEs and 12,424 TEs in corneal epithelial cells as well as 76,205 distal regulatory regions, marked by H3K4me1 alone (Fig. 1A). As expected, the majority of enhancers was found at distal sites in the genome rather than in proximal promoters (Fig. 1B). Although TEs showed a trend toward being localized near genes, SEs were even more strongly enriched near genes; most SEs were found within 50 kb of a transcriptional start site.Together, these data indicate that most epithelial distal regulatory regions are common to multiple epithelial cell types, differing only in the type of enhancer and/or the level of enhancer activity, as indicated by the activation mark H3K27Ac (Fig. 2C).

About Target gene

Target gene : PSORS1C1(C6orf16,SEEK1)
Strong evidence: --
Less strong evidence: Luciferase Reporter Assay,ChIP
Target gene experiment description: SNP rs3815087 is located in an exon of PSORS1C (Figure 7A), a gene identified as a psoriasis susceptibility locus, although evidence points to this SNP being non-coding as the exon in which it is located is not translated in any of PSORS1C’s known isoforms. SNP rs6758183 is located in a gene desert, approximately 500kb from the nearest coding gene (Figure 7A, 7B).When transfected into HCE cells, the genomic region of rs3815087 showed enhancer activity, and rs6758183 showed a trend toward increased activity compared with the negative control (Fig. 7C).In contrast, the region containing the disease-linked variant of rs6758183 showed significantly increased enhancer activity compared with the WT allele and significantly increased enhancer activity above the negative control (Fig. 7C).

About TF

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TF experiment: --
TF experiment description: --

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
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About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs