Enhancer ID: | E_01_254 | |
Enhancer symbol: | FOXC1 Enhancer | |
Species: | Human | |
Position : | chr6:1636681-1642781 |
|
Biosample name: | MCF-7 | |
Experiment class : | Low throughput |
Enhancer type: | Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 27932455 |
Enhancer experiment: | smFISH,ChIP | |
Enhancer experiment description: | Here we monitored the expression and localization of eRNAs derived from the enhancers of the FOXC1 and P2RY2 loci, as well as the expression of their cognate mRNAs over a time course of estrogen induction in individual MCF-7 cells by smFISH. In the uninduced state,FOXC1 and P2RY2 eRNAs were expressed at low levels, independently of MLL1 and ER. Estrogen treatment induced the transcription of eRNAs and target mRNAs with similar kinetics, and required both chromatin modiication by MLL1 and ER recruitment. |
Target gene : | FOXC1(ARA,ASGD3,FKHL7,FREAC-3,FREAC3,IGDA,IHG1,IRID1,RIEG3) | |
Strong evidence: | -- | |
Less strong evidence: | smFISH,ChIP | |
Target gene experiment description: | Here we monitored the expression and localization of eRNAs derived from the enhancers of the FOXC1 and P2RY2 loci, as well as the expression of their cognate mRNAs over a time course of estrogen induction in individual MCF-7 cells by smFISH. In the uninduced state,FOXC1 and P2RY2 eRNAs were expressed at low levels, independently of MLL1 and ER. Estrogen treatment induced the transcription of eRNAs and target mRNAs with similar kinetics, and required both chromatin modiication by MLL1 and ER recruitment. |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | eRNA accumulation at enhancer–promoter loops is not required to sustain target gene transcription. |
Enhancer function experiment: | 3C |
Enhancer function experiment description: |
Chromosome conformation capture (3C) analyses conducted in the presence or absence of Enhancer-derived transcripts proposed that eRNAs mediate Enhancer–promoter interactions . |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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