Enhancer ID: | E_01_238 | |
Enhancer symbol: | MYC Super-Enhancer | |
Species: | Human | |
Position : | chr8:130386715-130591515 |
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Biosample name: | Acute Myeloid Leukemia Cell | |
Experiment class : | Low throughput |
Enhancer type: | Super-Enhancer | |
Disease: | -- | |
DO: | -- | |
Mesh: | -- | |
Distance from TSS: | >2KB | |
Pubmed ID: | 26626481 |
Enhancer experiment: | ChIP,ChIP-qPCR | |
Enhancer experiment description: | BRD4 has been shown previously to regulate Myc expression in AML cell via a super-Enhancer (with individual Enhancer constituents E1-E5) located 1.7 Mb downstream of the Myc promoter. ChIP analysis revealed that H3K36 dimethylation, but not H3K36 mono- and tri-methylation, broadly correlated with NSD3-short occupancy at the Myc E1–E5 super-enhancer (Figures S5B and S5C and data not shown). Using the ectopically expressed FLAG-tagged NSD3-short, we confirmed the association of this isoform with the Myc E1–E5 super-enhancer using ChIP with anti-FLAG antibodies (Figure 6A). |
Target gene : | MYC(MRTLC,bHLHe39,c-Myc) | |
Strong evidence: | -- | |
Less strong evidence: | ChIP,ChIP-qPCR | |
Target gene experiment description: | BRD4 has been shown previously to regulate Myc expression in AML cell via a super-Enhancer (with individual Enhancer constituents E1-E5) located 1.7 Mb downstream of the Myc promoter. ChIP analysis revealed that H3K36 dimethylation, but not H3K36 mono- and tri-methylation, broadly correlated with NSD3-short occupancy at the Myc E1–E5 super-enhancer (Figures S5B and S5C and data not shown). Using the ectopically expressed FLAG-tagged NSD3-short, we confirmed the association of this isoform with the Myc E1–E5 super-enhancer using ChIP with anti-FLAG antibodies (Figure 6A). |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
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SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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