About Enhancer

Enhancer ID: E_01_238
Enhancer symbol: MYC Super-Enhancer
Species: Human
Position : chr8:130386715-130591515
Biosample name: Acute Myeloid Leukemia Cell
Experiment class : Low throughput
Enhancer type: Super-Enhancer
Disease: --
DO: --
Mesh: --
Distance from TSS: >2KB
Pubmed ID:  26626481
Enhancer experiment: ChIP,ChIP-qPCR
Enhancer experiment description: BRD4 has been shown previously to regulate Myc expression in AML cell via a super-Enhancer (with individual Enhancer constituents E1-E5) located 1.7 Mb downstream of the Myc promoter. ChIP analysis revealed that H3K36 dimethylation, but not H3K36 mono- and tri-methylation, broadly correlated with NSD3-short occupancy at the Myc E1–E5 super-enhancer (Figures S5B and S5C and data not shown). Using the ectopically expressed FLAG-tagged NSD3-short, we confirmed the association of this isoform with the Myc E1–E5 super-enhancer using ChIP with anti-FLAG antibodies (Figure 6A).

About Target gene

Target gene : MYC(MRTLC,bHLHe39,c-Myc)
Strong evidence: --
Less strong evidence: ChIP,ChIP-qPCR
Target gene experiment description: BRD4 has been shown previously to regulate Myc expression in AML cell via a super-Enhancer (with individual Enhancer constituents E1-E5) located 1.7 Mb downstream of the Myc promoter. ChIP analysis revealed that H3K36 dimethylation, but not H3K36 mono- and tri-methylation, broadly correlated with NSD3-short occupancy at the Myc E1–E5 super-enhancer (Figures S5B and S5C and data not shown). Using the ectopically expressed FLAG-tagged NSD3-short, we confirmed the association of this isoform with the Myc E1–E5 super-enhancer using ChIP with anti-FLAG antibodies (Figure 6A).

About TF

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TF experiment: --
TF experiment description: --

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
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About SNP

SNP ID: --
SNP position: --
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Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs