About Enhancer
| Enhancer ID: | E_01_230 | |
| Enhancer symbol: | CARDIAC Enhancer | |
| Species: | Human | |
| Position : | chr5:148785000-148815000   |
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| Biosample name: | Cardiac Progenitor Cell | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 26423156 |
| Enhancer experiment: | ChIP-seq,Immunohistochemistry,Luciferase Reporter Assay,RIP | |
| Enhancer experiment description: | Secondly, ChIP-analysis demonstrates that these transcripts mapped to a highly active cardiac enhancer in both fetal and adult human hearts (Fig. 3B). Notably, this region was shown to harbor a car_x0002_diac SRF/NKX2.5-bound enhancer required for cardiac-specific expres_x0002_sion of miR-143 and -145 during cardiac development.Furthermore, this enhancer has been previously demonstrated to be a Notch-responsive enhancer, capable of modulating miR-143 and -145 expressions in various developmental contexts.Accordingly, the enhancer was able to drive robust cardiac-specific activity in a mouse transgenic reporter assays at E11.5 p.c. (Fig. 3C). |
About Target gene
| Target gene : | NKX2-5(CHNG5,CSX,CSX1,HLHS2,NKX2.5,NKX2E,NKX4-1,VSD3) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq,Immunohistochemistry,Luciferase Reporter Assay,RIP | |
| Target gene experiment description: | These results indicated that the promoter of NOXA physically interacted with the mbr Enhancer over 3.4Mb and might form a promoter-promoter-mbr complex with the BCL2 promoter and the mbr Enhancer in nucleus through High throughputer-order Chroma_x0002_tin structures. |
About TF
| TF name : | -- | |
| TF experiment: | -- | |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
