About Enhancer
Enhancer ID: |
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E_01_224 |
Enhancer symbol: |
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Species: |
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Human |
Position : |
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chr6:1614188-1617051
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Biosample name: |
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Embryonic Stem Cell |
Experiment class : |
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Low+High throughput |
Enhancer type: |
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Enhancer |
Disease: |
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DO: |
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Mesh: |
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Distance from TSS: |
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>2KB |
Pubmed ID: |
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26382291 |
Enhancer experiment: |
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Enhancer Assay |
Enhancer experiment description: |
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We experimentally validate four novel Enhancers in this locus and demonstrate that these Enhancers show consistent activity during embryonic development in domains that overlap with the expression of FOXC1 and GMDS. |
About Target gene
Target gene : |
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FOXC1(ARA,ASGD3,FKHL7,FREAC-3,FREAC3,IGDA,IHG1,IRID1,RIEG3),GMDS(GMD,SDR3E1) |
Strong evidence: |
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Less strong evidence: |
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Enhancer Assay |
Target gene experiment description: |
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We experimentally validate four novel Enhancers in this locus and demonstrate that these Enhancers show consistent activity during embryonic development in domains that overlap with the expression of FOXC1 and GMDS. |
About TF
TF name : |
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ZIC1(CRS6,ZIC,ZNF201) |
TF experiment: |
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X-Gal Staining Assay |
TF experiment description: |
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An image from the UCSC Genome Browser showing the enhancer landscape near FOXC1 and GMDS.The lower panel is zoomed in to the regions immediately surrounding the enhancers, to highlight the ZIC1 binding sites. b E11.5 whole-mount images of ZIC mutants CE1–3. CE4 only yielded two X gal- positive embryos and was thus not used in the analysis. Tissues that have lacZ expression in at least half of the X-gal-positive embryos in WT but not in ZIC enhancers are noted in red. Arrowheads mark regions of interest. |
About Function
Enhancer function : |
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Enhancer function experiment: |
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Enhancer function experiment description: |
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About SNP
SNP ID: |
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-- |
SNP position: |
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Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
Expression of target genes for the enhancer
Enhancer associated SNPs