About Enhancer
| Enhancer ID: | E_01_148 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr1:226085596-226087967   |
|
| Biosample name: | Embryonic Stem Cell | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 24332857 |
| Enhancer experiment: | ChIP-seq,siRNA | |
| Enhancer experiment description: | Importantly, the SMAD DNA binding partner FOXH1, a major specifier of ME, is found near TSO elements, and upon fate specification，we show that TSO is disrupted with subsequent SMAD-FOXH1 induction of ME. These studies define switch-enhancer elements and provide a framework to understand how cellular context dictates interpre_x0002_tation of the same morphogen signal in development. |
About Target gene
| Target gene : | LEFTY1(LEFTB,LEFTYB) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq,PCR | |
| Target gene experiment description: | We first verified binding of TEAD4 and SMAD2 to the CTGF promoter and the LEFTY1 enhancer, respectively (Fig_x0002_ure S3B), and confirmed dramatic reduction in SMAD2 genome occupancy upon SB431542 treatment, as illustrated for the LEFTY1 locus (Figure S3B, lower panel). Inclusion of this control increased our ChIP-seq sensitivity, as reflected by more SMAD binding sites identified here when compared to others. |
About TF
| TF name : | POU5F1(OCT3,OCT4,OTF-3,OTF3,OTF4,Oct-3,Oct-4)SOX2(ANOP3,MCOPS3)NANOG(NANOG) | |
| TF experiment: | ChIP,PCR | |
| TF experiment description: | To verify the association of these transcription factors with the endogenous NANOG promoter,we performed ChIP. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
