About Enhancer
| Enhancer ID: | E_01_140 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr11:111150916-111155431   |
|
| Biosample name: | HCT 116,SW480,Colorectal Cancer | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | Colorectal Cancer | |
| DO: | DOID:9256 | |
| Mesh: | D015179 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 24256810 |
| Enhancer experiment: | PCR,ChIP-seq,Luciferase Reporter Assay,Transfection,EMSA | |
| Enhancer experiment description: | One potentially active promoter region and several candidate enhancer regions were identified using high-resolution genome wide ChIP-seq profiles for histone modifications including H3K4me1, H3K4me3 and H3K9/14ac (Figure 1A and Supple_x0002_mentary Material, Fig. S1), which we generated for the SW480 and HCT-116 CRC cell lines. |
About Target gene
| Target gene : | C11orf53(C11orf53) | |
| Strong evidence: | -- | |
| Less strong evidence: | ChIP-seq | |
| Target gene experiment description: | This is manifest in normal human colon tissues as eQTL for three genes, C11orf53, C11orf92 and C11orf93. Using bicolor EMSA, we further showed that protein binding is markedly dif_x0002_ferent for the sequences containing the two alleles of rs7130173,with binding affinity of the C allele roughly four times greater than the A allele. |
About TF
| TF name : | -- | |
| TF experiment: | -- | |
| TF experiment description: | -- |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | rs7130173 | |
| SNP position: | 111154072 |
| SNP experiment: | ChIP-seq,Luciferase Reporter Assay,EMSA |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
