Enhancer ID: | E_01_106 | |
Enhancer symbol: | ARE Enhancer | |
Species: | Human | |
Position : | chr22:35766960-35768960 |
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Biosample name: | HeLa | |
Experiment class : | Low throughput |
Enhancer type: | Enhancer | |
Disease: | Breast Cancer | |
DO: | DOID:1612 | |
Mesh: | D001943 | |
Distance from TSS: | >2KB | |
Pubmed ID: | 22370642 |
Enhancer experiment: | qPCR,ChIP | |
Enhancer experiment description: | Further_x0002_more, chromatin immunoprecipitation showed that RAC3 bound tightly to the ARE enhancer region of the HO-1 promoter via Nrf2 binding. These data suggest that Nrf2 activation is modulated and directly controlled through interactions with the RAC3 protein in HeLa cells. |
Target gene : | HMOX1(HMOX1D,HO-1,HSP32,bK286B10) | |
Strong evidence: | -- | |
Less strong evidence: | qPCR,ChIP | |
Target gene experiment description: | To determine the effects of RAC3 on the expression of HO-1, an Nrf2 target protein, HeLa cells were transfected with Nrf2 and various concentrations of HA-RAC3 plasmids. First, we measured the protein and mRNA levels of HO-1. The results showed that transfection with HA-RAC3 increased the HO-1 protein (Figure 1a) and mRNA levels (Figure 1b) in a dose_x0002_dependent manner in the presence of a yellow fluorescent protein (YFP)-Nrf2 construct. |
TF name : | NFE2L2(HEBP1,IMDDHH,NRF2) | |
TF experiment: | ChIP | |
TF experiment description: | To test this hypothesis,we conducted a chromatin immunoprecipitation (ChIP) assay to eluci_x0002_date whether the RAC3 protein was detectable on the ARE sequences bound to Nrf2. |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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