About Enhancer

Enhancer ID: E_01_106
Enhancer symbol: ARE Enhancer
Species: Human
Position : chr22:35766960-35768960
Biosample name: HeLa
Experiment class : Low throughput
Enhancer type: Enhancer
Disease: Breast Cancer
DO: DOID:1612
Mesh: D001943
Distance from TSS: >2KB
Pubmed ID:  22370642
Enhancer experiment: qPCR,ChIP
Enhancer experiment description: Further_x0002_more, chromatin immunoprecipitation showed that RAC3 bound tightly to the ARE enhancer region of the HO-1 promoter via Nrf2 binding. These data suggest that Nrf2 activation is modulated and directly controlled through interactions with the RAC3 protein in HeLa cells.

About Target gene

Target gene : HMOX1(HMOX1D,HO-1,HSP32,bK286B10)
Strong evidence: --
Less strong evidence: qPCR,ChIP
Target gene experiment description: To determine the effects of RAC3 on the expression of HO-1, an Nrf2 target protein, HeLa cells were transfected with Nrf2 and various concentrations of HA-RAC3 plasmids. First, we measured the protein and mRNA levels of HO-1. The results showed that transfection with HA-RAC3 increased the HO-1 protein (Figure 1a) and mRNA levels (Figure 1b) in a dose_x0002_dependent manner in the presence of a yellow fluorescent protein (YFP)-Nrf2 construct.

About TF

TF name : NFE2L2(HEBP1,IMDDHH,NRF2)
TF experiment: ChIP
TF experiment description: To test this hypothesis,we conducted a chromatin immunoprecipitation (ChIP) assay to eluci_x0002_date whether the RAC3 protein was detectable on the ARE sequences bound to Nrf2.

About Function

Enhancer function : --
Enhancer function experiment: --
Enhancer function
experiment description:
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About SNP

SNP ID: --
SNP position: --
SNP experiment: --

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs