About Enhancer
| Enhancer ID: | E_01_083 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr21:39823183-39825183   |
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| Biosample name: | T-acute lymphoblastic leukemia (T-ALL),Molt4,REH,416B | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Enhancer | |
| Disease: | T-Cell Acute Lymphoblastic Leukemia | |
| DO: | DOID:5602 | |
| Mesh: | D054218 | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 21536859 |
| Enhancer experiment: | Luciferase Reporter Assay,PCR,ChIP,ChIP-PCR,ChIP-seq | |
| Enhancer experiment description: | The ERG stem cell enhancer is active in human T-cell progenitors and in T-ALL.Graphs at right show these peaks of enrichment confirmed by ChIP-PCR. |
About Target gene
| Target gene : | ERG | |
| Strong evidence: | q3C | |
| Less strong evidence: | qPCR,ChIP-PCR | |
| Target gene experiment description: | Taken together, these results show that genomic sequences in the human ERG locus corresponding to the mouse Erg +85 enhancer are in an active configuration in CD34+ stem/progenitors, pro-T, and T-ALL cells. |
About TF
| TF name : | GATA2(DCML,IMD21,MONOMAC,NFE1B)LMO2(LMO-2,RBTN2,RBTNL1,RHOM2,TTG2)SCL(SCL)LYL1(bHLHa18) | |
| TF experiment: | ChIP-PCR | |
| TF experiment description: | ChIP-PCR analysis of TF binding. The enhancer has active chromatin marks (AcH3) in 416B blood progenitors as well as in T-ALL cells. There is strong LMO2 binding in all cell types, whereas SCL and LYL1 enrichments are more pronounced in T-ALL cells. The Ets factors, FLI1 and ERG, are also enriched in T-ALL cells. Consistent with their expression profiles, Gata2 is enriched at the _x0001_85 enhancer in 416B progenitors, whereas GATA3 is enriched in T-ALL cells. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
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About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
