About Enhancer
| Enhancer ID: | E_01_069 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr2:136582836-136583741   |
|
| Biosample name: | Caco-2,Cheek Cell | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 21445905 |
| Enhancer experiment: | Luciferase Reporter Assay,PCR,EMSA | |
| Enhancer experiment description: | In transient transfection experiments using Caco‐2 cells (a human colorectal adenocarcinoma cell line that mimics intestinal epithelial cells) and lactase promoter/luciferase gene constructs, small DNA fragments containing either the C−13,910 or T−13,910 variants of the enhancer region were shown to significantly increase the expression of the reporter gene when included in the constructs. |
About Target gene
| Target gene : | MCM6(MCG40308,Mis5,P105MCM) | |
| Strong evidence: | -- | |
| Less strong evidence: | Luciferase Reporter Assay,PCR, | |
| Target gene experiment description: | Map of the region of human chromosome 2q21 containing the human lactase (LCT) and minichromosome maintenance ‐6 (MCM6) genes (panel a). |
About TF
| TF name : | POU2F1(OCT1,OTF1,oct-1B) | |
| TF experiment: | EMSA | |
| TF experiment description: | In addition, the transcription factor Oct-1 was shown to bind more strongly to DNA fragments containing the T213,910 variant than the C213,910 variant in electrophoretic mobility shift assays. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | rs4988235 | |
| SNP position: | 136608646 |
| SNP experiment: | PCR |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
