About Enhancer
| Enhancer ID: | E_01_028 | |
| Enhancer symbol: | -- | |
| Species: | Human | |
| Position : | chr17:26072592-26074592   |
|
| Biosample name: | Hep G2 | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer | |
| Disease: | -- | |
| DO: | -- | |
| Mesh: | -- | |
| Distance from TSS: | >2KB | |
| Pubmed ID: | 19467240 |
| Enhancer experiment: | Luciferase Reporter Assay,PCR,EMSA,ChIP | |
| Enhancer experiment description: | Taken together, this work identifies a far-upstream functional Oct-1 enhancer motif at -10.2 kb in the hiNOS promoter that regulates cytokine-induced hiNOS gene transcription, and further underscores the tight control mechanisms regulating expression of the human iNOS gene. |
About Target gene
| Target gene : | NOS2(HEP-NOS,INOS,NOSA) | |
| Strong evidence: | -- | |
| Less strong evidence: | EMSA,ChIP | |
| Target gene experiment description: | Taken together, this work identifies a far-upstream functional Oct-1 enhancer motif at -10.2 kb in the hiNOS promoter that regulates cytokine-induced hiNOS gene transcription, and further underscores the tight control mechanisms regulating expression of the human iNOS gene. |
About TF
| TF name : | POU2F1(OCT1,OTF1,oct-1B) | |
| TF experiment: | EMSA,ChIP | |
| TF experiment description: | To examine whether the Oct-1 protein can interact with the potential Oct-1 binding site at ?10.2 kb of hiNOS in vitro, we carried out electrophoretic mobility shift assays (EMSAs) with nuclear extracts from HepG2 cells.Chromatin immunoprecipitation assay confirms that Oct-1 specifically binds to the motif at ?10.2 kb in the hiNOS promoter in vivo. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- | |
| SNP position: | -- |
| SNP experiment: | -- |
Enhancer associated network
The number on yellow line represents the distance between enhancer and target gene
