Enhancer ID: | E_01_016 | |
Enhancer symbol: | -- | |
Species: | Human | |
Position : | chr13:27523026-27544353 |
|
Biosample name: | Colon Crypt Cell | |
Experiment class : | Low+High throughput |
Enhancer type: | Super-Enhancer | |
Disease: | Colorectal Carcinoma | |
DO: | DOID:0080199 | |
Mesh: | D015179 | |
Distance from TSS: | >2KB | |
Pubmed ID: | 26656844 |
Enhancer experiment: | ChIP-seq,Luciferase Reporter Assay,3C-qPCR,CRISPR/Cas9,siRNA | |
Enhancer experiment description: | Additional focal amplification peaks on chromosome 13q in colorectal carcinoma (CRC) (~21 kb, chr. 13: 27,523,026–27,544,353) and chromosome 20q in liver hepatocellular carcinoma (~22 kb,chr. 20: 48,997,377–49,019,434) were identified. ChIP-seq profiling of H3K27ac in colon crypt cells31 and in the hepatocellular carcinoma cell line HepG2 (ref. 20) demonstrated that these amplicons contain super-enhancers. |
Target gene : | USP12(UBH1L1) | |
Strong evidence: | -- | |
Less strong evidence: | ChIP-seq | |
Target gene experiment description: | Right, log2-transformed expression level (RPKM) of USP12 in CRC tumors with focal amplification of USP12-CCSE (USP12 colorectal carcinoma super-enhancer) alone (n = 6) and tumors without the amplification (n = 127). (Fig. 1d) |
TF name : | -- | |
TF experiment: | -- | |
TF experiment description: | -- |
Enhancer function : | -- |
Enhancer function experiment: | -- |
Enhancer function experiment description: |
-- |
SNP ID: | -- | |
SNP position: | -- |
SNP experiment: | -- |
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