Pathway name:

Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101

Aging Type:

Inhibit

Aging characteristic:

cellular senescence

Category:

pathway

Phenotype:

Breast cancer

Experimental category:

L

Tissue type:

--

Cell name:

MCF-7

PMID:

21881167

Experiment:

SA-β-gal activity assay

Description:

Interestingly, constitutive activation of Akt-1 in the drug resistant cells [MCF7/△Akt-1(CA)DoxR] resulted in the complete abrogation of drug-induced senescence at all doses examined (Panel D), suggesting an interplay between active Akt-1 and other resistance mechanisms acquired by the MCF7/DoxR cells.

Pathway Network

Pathway name	Pathway source	Gene number	Edge number	Geneset
Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101	wikipathways	8	14	RAF1;ELAVL1;HIF1A;GSK3B;MAPK1;PRKCB;RUNX2;CRK