External factors
| Category: |
Chemical compounds |
| Cell name: |
MDA-MB-231 cancer cells |
| Experiment: |
Western blot//PCR |
| Description: |
Cytosolic expression of HMGB1 was increased in the ALA and ALA+RT groups, whereas nuclear expression levels of HMGB1 were decreased in these groups compared to the control. Moreover, expression levels of p53 and activation of p38 mitogen-activated protein kinase (MAPK) and NF- κB were significantly increased in the ALA+RT group compared to the control. The expres- sion levels of IL-6, IL-8, and Cxcl1 were measured by qPCR to additionally examine the effect of ALA on cellular senes - cence in irradiated cells. Increased levels of the correspond- ing mRNAs were observed in the ALA+RT group compared to all groups. The expression of p21, a cyclin- dependent kinase (Cdk) inhibitor that induces senescence through cell cycle arrest, was significantly increased in the ALA+RT group compared to the other groups. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
383
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| R-EF-Target gene:
|
Downregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
HMGB1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Cytosolic expression of HMGB1 was increased in the ALA and ALA+RT groups, whereas nuclear expression levels of HMGB1 were decreased in these groups compared to the control. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793