External factors
| External factors: |
HIV infection |
| Experiment: |
Confocal microscopy |
| Description: |
To determine telomeric DDR in HIV-infected SupT1 and primary CD4 T cells, we compared the number of TIFs by examining the co-localization of 53BP1 and TRF1 using confocal microscopy. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Western blot analysis of p24, ATM, CHK2, AKT, PARP-1, and γH2AX expressions in SupT1 cells at day 6 of HIV infection. |
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| Regulatory pathway:
|
PI3K-ATM |
| R-EF-Pathway:
|
Downregulation |
| Pathway experiment: |
Western blot |
| Pathway description: |
Western blot analysis of p24, ATM, CHK2, AKT, PARP-1, and γH2AX expressions in SupT1 cells at day 6 of HIV infection. B) Western blot analysis of p24, ATM, CHK2, AKT, PARP-1, andγH2AX expressions in primary CD4 cells at day 5 of HIV infection. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Pathway view
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