External factors
| External factors: |
Hinokitiol |
| Category: |
Chemical compounds |
| Phenotype: |
Cervical cancer |
| Experiment: |
SA-β-gal activity assay |
| Description: |
SA-β-gal assay results showed that ?hinokitiol treatment obviously increased β-galactosidase activity as ?compared with control. |
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Regulatory relationship
| Target gene:
|
CYCLIN D1//CYCLIN E |
| R-EF-Target gene:
|
Downregulation//Downregulation |
| Official symbol(s): |
CYCLIN D1//CYCLIN E |
| Target gene experiment: |
Western blot |
| Target gene description: |
Results of western ?blotting showed that the protein levels of cyclin D1 and cyclin E ?were significantly downregulated in cells treated with hinokitiol in ?a dose-dependent manner. |
| Regulatory pathway:
|
p53-p21 |
| Official symbol(s): |
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TP53-CDKN1A
|
| Pathway experiment: |
Western blot |
| Pathway description: |
An increase in both p21 and p53 level was ?observed in hinokitiol-treated cells. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.