External factors
| External factors: |
CPBMF65 |
| Category: |
Chemical compounds |
| Experiment: |
NMA analysis//Flow cytometry |
| Description: |
We also investigated whether treatment with CPBMF65 would induce senescence, another mechanism that may be involved in decreasing cell proliferation. A significant senescence increase of 9% in HepG2 cells treated with CPBMF65 was observed, while the positive control group (treated with H2O2, 150 μM) presented a 16% senescence increase. In order to explore if the Urd treatment was also capable of inducing senescence, the NMA assay was performed. Results demonstrated that 5 and 10 mM of Urd, as well as 150 μM of H2O2 (positive control), induced an increase of senescence in HepG2 cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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