External factors
| Category: |
Chemical compounds |
| Experiment: |
Immunochemical staining//RTCA |
| Description: |
D-Gal treatment greatly increased the percentage of AGEs-positive expression in the liver and kidney tissues, respectively, comparing with the normal control group. These results con- firmed the aging changes of the liver and kidney. In contrast, supple- ment of maltol at 50 and 100 mg/kg for 4 weeks effectively inhibited the expression of AGEs in the liver and kidney, suggesting clearly that maltol effectively prevent D-Gal-induced senescence in the liver and kidney.Long-time D-Gal treatment significantly enhanced theoverproduction of MDA and reduced the activity of SOD and CATwhen compared with normal control group,whereas this situation was reversed in the maltol-treatment groups.Real-time monitoring results showed that different con-centrations of maltol significantly improved HEK293 cells viabilitywithin 24 hr after D-Gal incubation. |
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Regulatory relationship
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| Regulatory pathway:
|
p53-p21-p16//PI3K-Akt |
| R-EF-Pathway:
|
Activation//Activation |
| Pathway experiment: |
Western blot//Western blot |
| Pathway description: |
Increased expressions of p53, p21, and p16 in the D-Gal-treated liver and kidney were observed compared to that in normal control group, confirming that the treatment of with D-Gal triggers both the key activation factors of aging, eventually leads to premature senescence of liver and kidney.More importantly, (删除？) western blot analy- sis also revealed that p53, p21, and p16 protein levels were all down- regulated in maltol treatment groups, further veri- fying again the antiaging effect of maltol.//The protein expression levels of p-PI3K and p-Akt were significantly decreased in liver and kidney tissues of D-Gal-induced mice. Treatment of maltol enhanced protein expression levels of PI3K and Akt phosphorylation. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Pathway view
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