External factors
| Category: |
Chemical compounds |
| Phenotype: |
Intervertebral disc degeneration |
| Experiment: |
SA-β-gal activity assay//CCK-8 assay |
| Description: |
SA-β-Gal staining assay showed that the antisenescence effect of USC-exos was mitigated, and it showed that SA-β-Gal staining-positive NPCs in USC shMATN3 -exos group increased compared to those in the USC conMATN3 -exos group but was still lower than the control group.The results revealed that the proliferation of NPCs was markedly promoted in response to USC-exos stimulation. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
TGFB1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
WB analysis of TGF-β canonical SMAD pathway and noncanonical pathway (AKT) activation. In the USCconMATN3-exos group, the level of TGF-β and the extent of p-SMAD, COL2, and ACAN expression were significantly increased. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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