External factors
| External factors: |
Resveratrol |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Colony formation assay |
| Description: |
SA-β-gal activity significantly increased in LP-MSCs compared with that in EP-MSCs(SIRT1 expression) treated with either EtOH or with resveratrol.The CFU-F assay was performed. The results showed that resveratrol enhanced the colony-forming ability of EP-MSCs. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
β-CATENIN |
| Target gene experiment: |
Western blot |
| Target gene description: |
Western blot results showed that in EP-MSCs, ERK phosphorylation was reduced by resveratrol, resulting in a decrease of Activate β-catenin (non-phosphorylated). |
| R-EF-Pathway:
|
Downregulation |
| Official symbol(s): |
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ERK
|
| Pathway experiment: |
Western blot |
| Pathway description: |
Western blot results showed that in EP-MSCs, ERK phosphorylation was reduced by resveratro. |
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.