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Aging Overview

External factors

External factors: Radiation
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Chronic myeloid leukemia
Experimental category: L
Tissue type: --
Cell name: K562
PMID: 18281522
Experiment: SA-β-gal activity assay//Flow cytometry
Description: After 5-day incubation, a substantial part of irradiated cells underwent phenotypic changes characteristic of senescence, associated with β-galactosidase staining. At the concentration used, STI571 alone did not induce such changes.Radiation alone induced a depletion of the G1- and S-phase compartments together with prolonged accumulation in the G2 phase.



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Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.




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