External factors
| External factors: |
SP600125+IR |
| Phenotype: |
Anaplastic thyroid cancer |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
We also observed that most of SP600125 plus IR-treated cells were still attached to dishes and had enlarged granular phenotype resembling senescent state.The number of SA-β-gal–positive cells was markedly increased when SP600125 was combined with irradiation, whereas singular treatment showed weak or moderate induction of SA-β-gal activity. Our previous study has demonstrated that the fraction of cell with high PKH-2 fluorescence and increased SSC represents senescent state (10).The combination treatment with both SP600125 and IR significantly increased the subpopulation of PKH-2hi/SSChi compared to singular treatment. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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