External factors
| External factors: |
Mitochondrial ROS |
| Phenotype: |
Mitochondrial Dysfunction |
| Experimental category: |
HL |
| Tissue type: |
Heart left ventricle |
| Cell name: |
Human Cardiac Progenitor Cell |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
Mitochondrial ROS was subsequently artificially increased while maintaining hypoxic conditions by inhibition of complex III with 100 μM antimycin A (AMA) for 9 days in hCPC-1%. However, a 220% increase in SA-β-gal+ positive cells was observed in hCPC-1% treated with AMA, suggesting mitochondrial ROS can directly drive hCPC senescence. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793