External factors
| External factors: |
High glucose |
| Experiment: |
BrdU assay//Western blot//SA-β-gal activity assay//Cell morphological analysis |
| Description: |
BMSCs cultured in HG exhibited a time-dependent reduction in cumulative PD and BrdU incorporation.Cells cultured in HG for 2 weeks already show increased p16 and p21. HG also induced a time-dependent increase in SA-βgal positive cells .By contrast, glucose at 25 mM induced morphological changes consistent with senescence. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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