External factors
| External factors: |
Sulfur mustard |
| Phenotype: |
Chronic wound healing |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Using a SM concentration of 40 μM (IC25), most of the MSC demonstrate a senescence typical expression of ?-galactosidase.In absence of SM, 37.0 ± 1.2% of all cells were positive for Ki-67 within the nucleus. With increasing concentration of SM the number of Ki-67 positive nucleus deceased to 0.8 ± 0.1% at IC25(40 μM). Under exposure of IC1(1 μM) the number of proliferating cells were decreased by 26%. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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