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Aging Overview

External factors

External factors: HIV infection
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: AIDS
Experimental category: L
Tissue type: Blood
Cell name: CD4 peripheral T-cell
PMID: 22735071
Experiment: Immunostaining//Flow cytometry
Description: However, although the memory T-cell subset did not show more activation, significantly higher levels of senescence and proliferation were observed in vertically HIV-infected patients than in the healthy subjects. Furthermore, the effector memory CD4 T cells of vertically HIV-infected subjects displayed higher senescence, activation and proliferation levels than healthy subjects. Regarding the TemRA CD4 T-cell subset, vertically HIV-infected subjects showed higher senescence and activation levels than healthy subjects,but similar levels of proliferation were observed.



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Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.




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