External factors
| External factors: |
UV irradiation |
| Description: |
mRNA expression of type I collagen, the major structural protein in the human skin, was significantly reduced by acute UV irradiation in the dermis.In contrast, mRNA expression of collagen-degrading MMP-1, the primary collagen-degrading enzyme in human skin, was significantly elevated by acute UV irradiation in the dermis.(Aging characteristics：reduced type I collagen production and increased fragmentation of the dermal collagenous extracellular matrix). |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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